Andras Tomesz, PhD

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	www.linkedin.com/in/tomesz
	www.tomesz.hu
	Eger \| Budapest \| Hungary

ABOUT

I am continuously seeking new challenges and passionate about learning and acquiring new skills.

As a Senior Product Manager, I’ve been leading end-to-end product development projects for over 18 years in the fields of dietary supplements, medical nutrition products, biotechnology, and health sciences. My work is driven by strategic thinking, scientific foundation, and data-informed decision-making, all integrated into a user-centered approach.

For me, a product is not just a commercial tool, but a value-creating process where scientific precision, user experience, and business return come together. I have extensive experience in developing localized international portfolios, managing research, designing educational systems, and building software-based decision support tools.

My goal is to deliver validated and innovative solutions that create real impact – professionally, commercially, and personally.

EXPERIENCES

2007 - Present Senior Product Manager
Vita Crystal Research | Slimbios Kft.

Management of end-to-end biotechnology R&D projects, from early-stage concept through launch and lifecycle management — delivering business value and customer trust.

Led the development and market launch of more than 100 products over 18 years.
Managed full product development lifecycle: data-driven strategic recommendations, project costs, formulation (based on scientific meta-analyses), efficacy validation (in vitro/in vivo), design, sourcing, QA, safety, and science-based marketing.
Successfully launched a localized product portfolio in Vietnam, adapted to regional consumer habits and market conditions.
Optimized and accelerated research by developing a cost-effective, rapid assay panel based on early epigenetic biomarkers (miRNA patterns) to detect carcinogenic or chemopreventive effects within 24 hours.
Acted as cross-functional lead between CEO, department heads, and scientific teams; developed workflows now used as internal standards.
Deliver 2–3 professional or educational presentations per week to audiences ranging from small workshops to events with several hundred participants, supporting brand awareness, credibility, and consumer trust.

2005 - 2010 Software Engineer and Developer

Developed websites, e-commerce platforms, and business systems based on custom requirements.
Built data visualization and decision support tools for business and logistics processes.
Managed all phases of the development cycle: design → implementation → operation.

EDUCATIONS

2022 PhD in Health Sciences
Department of Public Health Medicine | University of Pécs

Doctoral thesis: Development of an early biomarker assay panel to examine of carcinogenic and chemopreventive agents based on gene expression and microRNA expression changes.

Applied in practice, the five biomarker-based assay panel designed to predict carcinogenesis is provide a valuable tool for investigation of chemopreventive and/or complementary therapeutic tumor suppressor compounds, thus opening new opportunities for reducing tumor incidence and mortality by using them as a tool for primary, secondary, and tertiary prevention.

MTMT: The Hungarian Scientific Bibliography account (ID: 10051844)

NEW SCIENTIFIC FINDINGS

My research has confirmed the following new results:
1. The mTORC1 gene expression shows a statistically significant increase in the liver*, spleen*** and kidneys*** of female CBA/Ca mice 24 hours after DMBA exposure (*p<0.05; ***p<0.001).
2. The expression of miR-9-3 miRNA shows a statistically significant increase in the liver***, spleen*** and kidneys*** of female CBA/Ca mice 24 hours after DMBA exposure (***p<0.001).
3. The expression of miR-124-1 miRNA shows a statistically significant increase in the liver***, spleen*** and kidneys*** of female CBA/Ca mice 24 hours after DMBA exposure (***p<0.001).
4. The expression of miR-132 miRNA shows a statistically significant increase in the liver***, spleen*** and kidneys*** of female CBA/Ca mice 24 hours after DMBA exposure (***p<0.001).
5. The expression of miR-134 miRNA expression shows a statistically significant increase in the liver***, spleen*** and kidneys*** of female CBA/Ca mice 24 hours after DMBA exposure (***p<0.001).
6. Increases in the expression of miR-9-3, miR-124-1, miR-132, and miR-134 miRNAs and mTORC1 genes are early biomarkers of DMBA-induced carcinogenicity in the liver, spleen and kidneys of female CBA/Ca mice 24 hours after exposure.

PUBLICATIONS, CONFERENCES - TOTAL IF: 31,632

Tomesz A, Szabo L, Molnar R, Deutsch A, Darago R, Raposa BL, Ghodratollah N, Varjas T, Nemeth B, Orsos Z, Pozsgai E, Szentpeteri JL, Budan F, Kiss I.
Changes in miR-124-1, miR-212, miR-132, miR-134, and miR-155 Expression Patterns after 7,12-Dimethylbenz(a)anthracene Treatment in CBA/Ca Mice.
Cells. 2022 Mar 17;11(6):1020. IF: 7.666

Tomesz A, Szabo L, Molnar R, Deutsch A, Darago R, Mathe D, Budan F, Ghodratollah N, Varjas T, Kiss I.
Effect of 7,12-Dimethylbenz(α)anthracene on the Expression of miR-330, miR-29a, miR-9-1, miR-9-3 and the mTORC1 Gene in CBA/Ca Mice.
In Vivo. 2020 Sep-Oct;34(5):2337-2343. IF: 2.09

Molnar R, Szabo L, Tomesz A, Deutsch A, Darago R, Raposa BL, Ghodratollah N, Varjas T, Nemeth B, Orsos Z, Pozsgai E, Szentpeteri JL, Budan F, Kiss I.
The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers.
Cells. 2022 Apr 12;11(8):1300. IF: 7.666

Szabo L, Molnar R, Tomesz A, Deutsch A, Darago R, Varjas T, Ritter Z, Szentpeteri JL, Andreidesz K, Mathe D, Hegedüs I, Sik A, Budan F, Kiss I.
Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model.
Nutrients. 2022 Feb 21;14(4):908. IF: 6.706

Szabo L, Molnar R, Tomesz A, Deutsch A, Darago R, Nowrasteh G, Varjas T, Nemeth B, Budan F, Kiss I.
The effects of flavonoids, green tea polyphenols and coffee on DMBA induced LINE-1 DNA hypomethylation.
PLoS One. 2021 Apr 20;16(4):e0250157. IF: 3.752

Molnar R, Szabo L, Tomesz A, Deutsch A, Darago R, Ghodratollah N, Varjas T, Nemeth B, Budan F, Kiss I.
In vivo effects of olive oil and trans-fatty acids on miR-134, miR-132, miR-124-1, miR-9-3 and mTORC1 gene expression in a DMBA-treated mouse model.
PLoS One. 2021 Feb 4;16(2):e0246022. IF: 3.752

Andreidesz K, Szabo L, Molnar R, Tomesz A, Darago R, Deutsch A, Ritter Zs, Szentpeteri LJ, Mathe D et al.
Trans-fatty acids enhance the DNA hypomethylation of LINE-1 retrotansposon in DMBA environmental carcinogen model.
51st MEMBRANE TRANSPORT CONFERENCE POSTERS ABSTRACTS 2022.

Budan F, Szabo L, Molnar R, Tomesz A, Varjas T, Ritter Zs, Szentpeteri LJ, Mathe D, Hegedus I, Sik A et al.
Extra virgin olive oil reduces the L1-RTP hypomethylating effect of the carcinogen DMBA.
51st MEMBRANE TRANSPORT CONFERENCE POSTERS ABSTRACTS 2022.

2015 Master's degree, Faculty of Adult Education and Human Resource Development
Faculty of Adult Education and Human Resource Development, University of Pécs

Thesis: The nature of work-related stress, with a focus on stressor identification, management strategies, and the role of dietary supplementation.

2007 Bachelor's degree, Faculty of Computer Engineering
Faculty of Computer Engineering | University of Dunaújváros

Thesis: Development and implementation of an online gradebook system.
A new opportunity for daily online communication between teachers and parents.

LANGUAGES

English: Full professional proficiency
German: Elementary
Hungarian: Native

OTHERS